diff --git a/qa/rpc-tests/import-rescan.py b/qa/rpc-tests/import-rescan.py
index 4a86c670b..a04c3df61 100755
--- a/qa/rpc-tests/import-rescan.py
+++ b/qa/rpc-tests/import-rescan.py
@@ -112,7 +112,8 @@ class ImportRescanTest(BitcoinTestFramework):
         extra_args = [["-debug=1"] for _ in range(self.num_nodes)]
         for i, import_node in enumerate(IMPORT_NODES, 1):
             if import_node.prune:
-                extra_args[i] += ["-prune=1"]
+                # txindex is enabled by default in Dash and needs to be disabled for import-rescan.py
+                extra_args[i] += ["-prune=1", "-txindex=0", "-reindex-chainstate"]
 
         self.nodes = start_nodes(self.num_nodes, self.options.tmpdir, extra_args)
         for i in range(1, self.num_nodes):
diff --git a/src/init.cpp b/src/init.cpp
index 67cf81ff3..5522d93d3 100644
--- a/src/init.cpp
+++ b/src/init.cpp
@@ -1745,7 +1745,8 @@ bool AppInitMain(boost::thread_group& threadGroup, CScheduler& scheduler)
     fMasternodeMode = GetBoolArg("-masternode", false);
     // TODO: masternode should have no wallet
 
-    if((fMasternodeMode || masternodeConfig.getCount() > -1) && fTxIndex == false) {
+    if((fMasternodeMode || masternodeConfig.getCount() > -1) && fTxIndex == false
+       && chainparams.NetworkIDString() != CBaseChainParams::REGTEST) { // TODO remove this when pruning is fixed. See https://github.com/dashpay/dash/pull/1817 and https://github.com/dashpay/dash/pull/1743
         return InitError("Enabling Masternode support requires turning on transaction indexing."
                   "Please add txindex=1 to your configuration and start with -reindex");
     }