diff --git a/.cirrus.yml b/.cirrus.yml
index 506bfceb21..2dd109af6a 100644
--- a/.cirrus.yml
+++ b/.cirrus.yml
@@ -37,7 +37,7 @@ task:
   timeout_in: 60m
   env:
     MAKEJOBS: "-j9"
-    RUN_CI_ON_HOST: "1"
+    DANGER_RUN_CI_ON_HOST: "1"
     CCACHE_SIZE: "200M"
     CCACHE_DIR: "/tmp/ccache_dir"
   ccache_cache:
diff --git a/.travis.yml b/.travis.yml
index ebaa556473..32f7b92fdd 100644
--- a/.travis.yml
+++ b/.travis.yml
@@ -32,9 +32,6 @@ cache:
   ccache: true
   directories:
     - $BASE_BUILD_DIR/ci/scratch/.ccache
-    # macOS
-    - $HOME/Library/Caches/Homebrew
-    - /usr/local/Homebrew
 before_cache:
   - if [ "${TRAVIS_OS_NAME}" = "osx" ]; then brew cleanup; fi
 env:
@@ -212,6 +209,26 @@ after_success:
         FILE_ENV="./ci/test/00_setup_env_arm.sh"
         QEMU_USER_CMD=""
 
+    - stage: test
+      name: 's390x native BE [GOAL: install] [bionic] [no depends, no GUI]'
+      arch: s390x
+      dist: bionic
+      addons:
+        apt:
+          packages:
+            - bsdmainutils
+            - libboost-filesystem-dev
+            - libboost-system-dev
+            - libboost-test-dev
+            - libboost-thread-dev
+            - libdb++-dev
+            - libdb-dev
+            - libevent-dev
+      env: >-
+        DANGER_RUN_CI_ON_HOST=true
+        CI_USE_APT_INSTALL=no
+        FILE_ENV="./ci/test/00_setup_env_s390x_host.sh"
+
 # s390 build was disabled temporarily because of disk space issues on the Travis VM
 #
 #    - stage: test
@@ -264,6 +281,12 @@ after_success:
       # Xcode 11.3.1, macOS 10.14, SDK 10.15
       # https://docs.travis-ci.com/user/reference/osx/#macos-version
       osx_image: xcode11.3
+      cache:
+        directories:
+          - $TRAVIS_BUILD_DIR/ci/scratch/.ccache
+          - $TRAVIS_BUILD_DIR/releases/$HOST
+          - $HOME/Library/Caches/Homebrew
+          - /usr/local/Homebrew
       addons:
         homebrew:
           packages:
@@ -277,4 +300,6 @@ after_success:
           - ccache
           - zeromq
       env: >-
+        DANGER_RUN_CI_ON_HOST=true
+        CI_USE_APT_INSTALL=no
         FILE_ENV="./ci/test/00_setup_env_mac_host.sh"
diff --git a/ci/test/00_setup_env_mac_host.sh b/ci/test/00_setup_env_mac_host.sh
index a43d715a65..dea7925e85 100755
--- a/ci/test/00_setup_env_mac_host.sh
+++ b/ci/test/00_setup_env_mac_host.sh
@@ -9,7 +9,6 @@ export LC_ALL=C.UTF-8
 export CONTAINER_NAME=ci_macos
 export HOST=x86_64-apple-darwin19
 export PIP_PACKAGES="zmq"
-export RUN_CI_ON_HOST=true
 export RUN_UNIT_TESTS=true
 export RUN_INTEGRATION_TESTS=false
 export GOAL="install"
diff --git a/ci/test/00_setup_env_s390x_host.sh b/ci/test/00_setup_env_s390x_host.sh
new file mode 100644
index 0000000000..8f3063604e
--- /dev/null
+++ b/ci/test/00_setup_env_s390x_host.sh
@@ -0,0 +1,14 @@
+#!/usr/bin/env bash
+#
+# Copyright (c) 2019 The Bitcoin Core developers
+# Distributed under the MIT software license, see the accompanying
+# file COPYING or http://www.opensource.org/licenses/mit-license.php.
+
+export LC_ALL=C.UTF-8
+
+export HOST=s390x-linux-gnu
+export NO_DEPENDS=1
+export BITCOIN_CONFIG="--with-incompatible-bdb --enable-reduce-exports"
+export RUN_UNIT_TESTS=true
+export RUN_FUNCTIONAL_TESTS=true
+export GOAL="install"
diff --git a/ci/test/04_install.sh b/ci/test/04_install.sh
index 9a5d4e0242..92ef17c302 100755
--- a/ci/test/04_install.sh
+++ b/ci/test/04_install.sh
@@ -34,7 +34,7 @@ fi
 
 export P_CI_DIR="$PWD"
 
-if [ -z "$RUN_CI_ON_HOST" ]; then
+if [ -z "$DANGER_RUN_CI_ON_HOST" ]; then
   echo "Creating $DOCKER_NAME_TAG container to run in"
   ${CI_RETRY_EXE} docker pull "$DOCKER_NAME_TAG"
 
@@ -65,7 +65,7 @@ fi
 if [[ $DOCKER_NAME_TAG == centos* ]]; then
   ${CI_RETRY_EXE} DOCKER_EXEC yum -y install epel-release
   ${CI_RETRY_EXE} DOCKER_EXEC yum -y install $DOCKER_PACKAGES $PACKAGES
-elif [ "$TRAVIS_OS_NAME" != "osx" ]; then
+elif [ "$CI_USE_APT_INSTALL" != "no" ]; then
   ${CI_RETRY_EXE} DOCKER_EXEC apt-get update
   ${CI_RETRY_EXE} DOCKER_EXEC apt-get install --no-install-recommends --no-upgrade -y $PACKAGES $DOCKER_PACKAGES
 fi
@@ -76,6 +76,7 @@ if [ "$TRAVIS_OS_NAME" == "osx" ]; then
 else
   DOCKER_EXEC free -m -h
   DOCKER_EXEC echo "Number of CPUs \(nproc\):" \$\(nproc\)
+  DOCKER_EXEC echo $(lscpu | grep Endian)
   DOCKER_EXEC echo "Free disk space:"
   DOCKER_EXEC df -h
 fi
@@ -89,7 +90,7 @@ export DIR_FUZZ_IN=${DIR_QA_ASSETS}/fuzz_seed_corpus/
 
 DOCKER_EXEC mkdir -p "${BASE_SCRATCH_DIR}/sanitizer-output/"
 
-if [ -z "$RUN_CI_ON_HOST" ]; then
+if [ -z "$DANGER_RUN_CI_ON_HOST" ]; then
   echo "Create $BASE_ROOT_DIR"
   DOCKER_EXEC rsync -a /ro_base/ $BASE_ROOT_DIR
 fi