diff --git a/depends/.gitignore b/depends/.gitignore
index 72734102c5..19c506ce54 100644
--- a/depends/.gitignore
+++ b/depends/.gitignore
@@ -8,5 +8,7 @@ i686*
 mips*
 arm*
 aarch64*
+powerpc*
 riscv32*
 riscv64*
+s390x*
diff --git a/depends/Makefile b/depends/Makefile
index bdd2e85a40..dc429d4920 100644
--- a/depends/Makefile
+++ b/depends/Makefile
@@ -245,7 +245,7 @@ $(host_prefix)/share/config.site: check-packages
 check-packages: check-sources
 
 clean-all: clean
-	@rm -rf $(SOURCES_PATH) x86_64* i686* mips* arm* aarch64* riscv32* riscv64*
+	@rm -rf $(SOURCES_PATH) x86_64* i686* mips* arm* aarch64* powerpc* riscv32* riscv64* s390x*
 
 clean:
 	@rm -rf $(WORK_PATH) $(BASE_CACHE) $(BUILD)
diff --git a/depends/README.md b/depends/README.md
index f470dd737a..b5296e63a7 100644
--- a/depends/README.md
+++ b/depends/README.md
@@ -12,13 +12,13 @@ For example:
 
     make HOST=x86_64-w64-mingw32 -j4
 
-**Dash's configure script by default will ignore the depends output.** In
+**Dash Core's configure script by default will ignore the depends output.** In
 order for it to pick up libraries, tools, and settings from the depends build,
 you must point it at the appropriate `--prefix` directory generated by the
 build. In the above example, a prefix dir named x86_64-w64-mingw32 will be
 created. To use it for Dash:
 
-    ./configure --prefix=`pwd`/depends/x86_64-w64-mingw32
+    ./configure --prefix=$PWD/depends/x86_64-w64-mingw32
 
 Common `host-platform-triplets` for cross compilation are:
 
@@ -28,8 +28,11 @@ Common `host-platform-triplets` for cross compilation are:
 - `x86_64-apple-darwin19` for macOS
 - `arm-linux-gnueabihf` for Linux ARM 32 bit
 - `aarch64-linux-gnu` for Linux ARM 64 bit
+- `powerpc64-linux-gnu` for Linux POWER 64-bit (big endian)
+- `powerpc64le-linux-gnu` for Linux POWER 64-bit (little endian)
 - `riscv32-linux-gnu` for Linux RISC-V 32 bit
 - `riscv64-linux-gnu` for Linux RISC-V 64 bit
+- `s390x-linux-gnu` for Linux S390X
 - `armv7a-linux-android` for Android ARM 32 bit
 - `aarch64-linux-android` for Android ARM 64 bit
 - `i686-linux-android` for Android x86 32 bit
@@ -66,6 +69,10 @@ For linux AARCH64 cross compilation:
 
     sudo apt-get install g++-aarch64-linux-gnu binutils-aarch64-linux-gnu
 
+For linux POWER 64-bit cross compilation (there are no packages for 32-bit):
+
+    sudo apt-get install g++-powerpc64-linux-gnu binutils-powerpc64-linux-gnu g++-powerpc64le-linux-gnu binutils-powerpc64le-linux-gnu
+
 For linux RISC-V 64-bit cross compilation (there are no packages for 32-bit):
 
     sudo apt-get install g++-riscv64-linux-gnu binutils-riscv64-linux-gnu
@@ -73,6 +80,10 @@ For linux RISC-V 64-bit cross compilation (there are no packages for 32-bit):
 RISC-V known issue: gcc-7.3.0 and gcc-7.3.1 result in a broken `test_dash` executable (see https://github.com/bitcoin/bitcoin/pull/13543),
 this is apparently fixed in gcc-8.1.0.
 
+For linux S390X cross compilation:
+
+    sudo apt-get install g++-s390x-linux-gnu binutils-s390x-linux-gnu
+
 ### Dependency Options
 The following can be set when running make: `make FOO=bar`
 
diff --git a/depends/packages/qt.mk b/depends/packages/qt.mk
index 37e913ff86..7c64e8b65d 100644
--- a/depends/packages/qt.mk
+++ b/depends/packages/qt.mk
@@ -151,7 +151,10 @@ else
 $(package)_config_opts_x86_64_linux = -xplatform linux-g++-64
 endif
 $(package)_config_opts_aarch64_linux = -xplatform linux-aarch64-gnu-g++
+$(package)_config_opts_powerpc64_linux = -platform linux-g++ -xplatform bitcoin-linux-g++
+$(package)_config_opts_powerpc64le_linux = -platform linux-g++ -xplatform bitcoin-linux-g++
 $(package)_config_opts_riscv64_linux = -platform linux-g++ -xplatform bitcoin-linux-g++
+$(package)_config_opts_s390x_linux = -platform linux-g++ -xplatform bitcoin-linux-g++
 
 $(package)_config_opts_mingw32 = -no-opengl
 $(package)_config_opts_mingw32 += -no-dbus