diff --git a/contrib/guix/guix-build b/contrib/guix/guix-build
index 415e97c57d..1fef7400f5 100755
--- a/contrib/guix/guix-build
+++ b/contrib/guix/guix-build
@@ -74,7 +74,8 @@ mkdir -p "$VERSION_BASE"
 ################
 
 # Default to building for all supported HOSTs (overridable by environment)
-export HOSTS="${HOSTS:-x86_64-linux-gnu arm-linux-gnueabihf aarch64-linux-gnu riscv64-linux-gnu powerpc64-linux-gnu powerpc64le-linux-gnu
+# powerpc64le-linux-gnu currently disabled due non-determinism issues across build arches.
+export HOSTS="${HOSTS:-x86_64-linux-gnu arm-linux-gnueabihf aarch64-linux-gnu riscv64-linux-gnu powerpc64-linux-gnu
                        x86_64-w64-mingw32
                        x86_64-apple-darwin arm64-apple-darwin}"
 
diff --git a/contrib/guix/manifest.scm b/contrib/guix/manifest.scm
index b49b8f15b6..ca03dc0385 100644
--- a/contrib/guix/manifest.scm
+++ b/contrib/guix/manifest.scm
@@ -94,7 +94,7 @@ chain for " target " development."))
       (home-page (package-home-page xgcc))
       (license (package-license xgcc)))))
 
-(define base-gcc gcc-10)
+(define base-gcc gcc-12)
 (define base-linux-kernel-headers linux-libre-headers-6.1)
 
 (define* (make-bitcoin-cross-toolchain target
@@ -565,9 +565,6 @@ inspecting signatures in Mach-O binaries.")
         automake
         pkg-config
         bison
-        ;; Native GCC 10 toolchain
-        gcc-toolchain-10
-        (list gcc-toolchain-10 "static")
         ;; Scripting
         python-minimal ;; (3.10)
         ;; Git
@@ -576,14 +573,25 @@ inspecting signatures in Mach-O binaries.")
         python-lief)
   (let ((target (getenv "HOST")))
     (cond ((string-suffix? "-mingw32" target)
-           ;; Windows
-           (list zip
+           (list ;; Native GCC 12 toolchain
+                 gcc-toolchain-12
+                 (list gcc-toolchain-12 "static")
+                 zip
                  (make-mingw-pthreads-cross-toolchain "x86_64-w64-mingw32")
                  nsis-x86_64
                  nss-certs
                  osslsigncode))
           ((string-contains target "-linux-")
-           (list (make-bitcoin-cross-toolchain target)))
+           (list ;; Native GCC 12 toolchain
+                 gcc-toolchain-12
+                 (list gcc-toolchain-12 "static")
+                 (make-bitcoin-cross-toolchain target)))
           ((string-contains target "darwin")
-           (list clang-toolchain-10 binutils xorriso python-signapple))
+           (list ;; Native GCC 10 toolchain
+                 gcc-toolchain-10
+                 (list gcc-toolchain-10 "static")
+                 binutils
+                 clang-toolchain-10
+                 python-signapple
+                 xorriso))
           (else '())))))
diff --git a/contrib/guix/patches/vmov-alignment.patch b/contrib/guix/patches/vmov-alignment.patch
index 7976b864af..96e1cb7cd1 100644
--- a/contrib/guix/patches/vmov-alignment.patch
+++ b/contrib/guix/patches/vmov-alignment.patch
@@ -168,14 +168,19 @@ Based on a patch originally by Claude Heiland-Allen <claude@mathr.co.uk>
  	default:
  	  gcc_unreachable ();
  	}
---- a/gcc/config/i386/i386.c
-+++ b/gcc/config/i386/i386.c
-@@ -4981,13 +4981,13 @@
-       switch (type)
+--- a/gcc/config/i386/i386.cc
++++ b/gcc/config/i386/i386.cc
+@@ -5418,17 +5418,15 @@ ix86_get_ssemov (rtx *operands, unsigned size,
  	{
  	case opcode_int:
--	  opcode = misaligned_p ? "vmovdqu32" : "vmovdqa32";
-+	  opcode = "vmovdqu32";
+ 	  if (scalar_mode == E_HFmode)
+-	    opcode = (misaligned_p
+-		      ? (TARGET_AVX512BW ? "vmovdqu16" : "vmovdqu64")
+-		      : "vmovdqa64");
++	    opcode = TARGET_AVX512BW ? "vmovdqu16" : "vmovdqu64";
+ 	  else
+-	    opcode = misaligned_p ? "vmovdqu32" : "vmovdqa32";
++	    opcode = "vmovdqu32";
  	  break;
  	case opcode_float:
 -	  opcode = misaligned_p ? "vmovups" : "vmovaps";
@@ -187,9 +192,24 @@ Based on a patch originally by Claude Heiland-Allen <claude@mathr.co.uk>
  	  break;
  	}
      }
-@@ -4996,16 +4996,16 @@
-       switch (scalar_mode)
+@@ -5438,29 +5436,21 @@ ix86_get_ssemov (rtx *operands, unsigned size,
  	{
+ 	case E_HFmode:
+ 	  if (evex_reg_p)
+-	    opcode = (misaligned_p
+-		      ? (TARGET_AVX512BW
+-			 ? "vmovdqu16"
+-			 : "vmovdqu64")
+-		      : "vmovdqa64");
++	    opcode = TARGET_AVX512BW ? "vmovdqu16" : "vmovdqu64";
+ 	  else
+-	    opcode = (misaligned_p
+-		      ? (TARGET_AVX512BW
+-			 ? "vmovdqu16"
+-			 : "%vmovdqu")
+-		      : "%vmovdqa");
++	    opcode = TARGET_AVX512BW ? "vmovdqu16" : "%vmovdqu";
+ 	  break;
  	case E_SFmode:
 -	  opcode = misaligned_p ? "%vmovups" : "%vmovaps";
 +	  opcode = "%vmovups";
@@ -208,7 +228,7 @@ Based on a patch originally by Claude Heiland-Allen <claude@mathr.co.uk>
  	  break;
  	default:
  	  gcc_unreachable ();
-@@ -5017,48 +5017,32 @@
+@@ -5472,48 +5462,32 @@ ix86_get_ssemov (rtx *operands, unsigned size,
  	{
  	case E_QImode:
  	  if (evex_reg_p)