diff --git a/configure.ac b/configure.ac
index 1c004cf4a4..7df52f6e77 100644
--- a/configure.ac
+++ b/configure.ac
@@ -232,12 +232,25 @@ case $host in
 
        AC_CHECK_PROG([BREW],brew, brew)
        if test x$BREW = xbrew; then
-         dnl add default homebrew paths
-         openssl_prefix=`$BREW --prefix openssl`
-         bdb_prefix=`$BREW --prefix berkeley-db4`
-         export PKG_CONFIG_PATH="$openssl_prefix/lib/pkgconfig:$PKG_CONFIG_PATH"
-         CPPFLAGS="$CPPFLAGS -I$bdb_prefix/include"
-         LIBS="$LIBS -L$bdb_prefix/lib"
+         dnl These Homebrew packages may be bottled, meaning that they won't be found
+         dnl in expected paths because they may conflict with system files. Ask
+         dnl Homebrew where each one is located, then adjust paths accordingly.
+         dnl It's safe to add these paths even if the functionality is disabled by
+         dnl the user (--without-wallet or --without-gui for example).
+
+         openssl_prefix=`$BREW --prefix openssl 2>/dev/null`
+         bdb_prefix=`$BREW --prefix berkeley-db4 2>/dev/null`
+         qt5_prefix=`$BREW --prefix qt5 2>/dev/null`
+         if test x$openssl_prefix != x; then
+           export PKG_CONFIG_PATH="$openssl_prefix/lib/pkgconfig:$PKG_CONFIG_PATH"
+         fi
+         if test x$bdb_prefix != x; then
+           CPPFLAGS="$CPPFLAGS -I$bdb_prefix/include"
+           LIBS="$LIBS -L$bdb_prefix/lib"
+         fi
+         if test x$qt5_prefix != x; then
+           export PKG_CONFIG_PATH="$qt5_prefix/lib/pkgconfig:$PKG_CONFIG_PATH"
+         fi
        fi
      else
        case $build_os in
diff --git a/src/m4/bitcoin_qt.m4 b/src/m4/bitcoin_qt.m4
index e71ecd7172..20fead2c1e 100644
--- a/src/m4/bitcoin_qt.m4
+++ b/src/m4/bitcoin_qt.m4
@@ -94,6 +94,12 @@ AC_DEFUN([BITCOIN_QT_CONFIGURE],[
     BITCOIN_QT_CHECK([_BITCOIN_QT_FIND_LIBS_WITHOUT_PKGCONFIG])
   fi
 
+  if test x$use_pkgconfig$qt_bin_path = xyes; then
+    if test x$bitcoin_qt_got_major_vers = x5; then
+      qt_bin_path="`$PKG_CONFIG --variable=host_bins Qt5Core 2>/dev/null`"
+    fi
+  fi
+
   BITCOIN_QT_PATH_PROGS([MOC], [moc-qt${bitcoin_qt_got_major_vers} moc${bitcoin_qt_got_major_vers} moc], $qt_bin_path)
   BITCOIN_QT_PATH_PROGS([UIC], [uic-qt${bitcoin_qt_got_major_vers} uic${bitcoin_qt_got_major_vers} uic], $qt_bin_path)
   BITCOIN_QT_PATH_PROGS([RCC], [rcc-qt${bitcoin_qt_got_major_vers} rcc${bitcoin_qt_got_major_vers} rcc], $qt_bin_path)