diff --git a/bitcoin-qt.pro b/bitcoin-qt.pro
index 9b2a193acc..6b1fb7f6cf 100644
--- a/bitcoin-qt.pro
+++ b/bitcoin-qt.pro
@@ -211,10 +211,10 @@ isEmpty(BOOST_INCLUDE_PATH) {
 }
 
 windows:LIBS += -lws2_32 -lgdi32
-windows:DEFINES += __WXMSW__
+windows:DEFINES += WIN32
 windows:RC_FILE = src/qt/res/bitcoin-qt.rc
 
-macx:DEFINES += __WXMAC_OSX__ MSG_NOSIGNAL=0 BOOST_FILESYSTEM_VERSION=3
+macx:DEFINES += MAC_OSX MSG_NOSIGNAL=0 BOOST_FILESYSTEM_VERSION=3
 macx:ICON = src/qt/res/icons/bitcoin.icns
 macx:TARGET = "Bitcoin Qt"
 
diff --git a/src/crypter.cpp b/src/crypter.cpp
index 9a8e6ca89a..bee7a3624b 100644
--- a/src/crypter.cpp
+++ b/src/crypter.cpp
@@ -7,7 +7,7 @@
 #include <vector>
 #include <string>
 #include "headers.h"
-#ifdef __WXMSW__
+#ifdef WIN32
 #include <windows.h>
 #endif
 
diff --git a/src/db.cpp b/src/db.cpp
index f69bab4dff..7de1f8df9a 100644
--- a/src/db.cpp
+++ b/src/db.cpp
@@ -658,7 +658,7 @@ int CWalletDB::LoadWallet(CWallet* pwallet)
     vector<uint256> vWalletUpgrade;
 
     // Modify defaults
-#ifndef __WXMSW__
+#ifndef WIN32
     // Tray icon sometimes disappears on 9.10 karmic koala 64-bit, leaving no way to access the program
     fMinimizeToTray = false;
     fMinimizeOnClose = false;
diff --git a/src/headers.h b/src/headers.h
index 17e9b3bc52..1e174da0de 100644
--- a/src/headers.h
+++ b/src/headers.h
@@ -22,7 +22,7 @@
 #if (defined(__unix__) || defined(unix)) && !defined(USG)
 #include <sys/param.h>  // to get BSD define
 #endif
-#ifdef __WXMAC_OSX__
+#ifdef MAC_OSX
 #ifndef BSD
 #define BSD 1
 #endif
@@ -51,7 +51,7 @@
 
 #include <boost/foreach.hpp>
 
-#ifdef __WXMSW__
+#ifdef WIN32
 #include <windows.h>
 #include <winsock2.h>
 #include <mswsock.h>
diff --git a/src/init.cpp b/src/init.cpp
index f09e1d019e..28be7ef7c0 100644
--- a/src/init.cpp
+++ b/src/init.cpp
@@ -24,7 +24,7 @@ CWallet* pwalletMain;
 
 void ExitTimeout(void* parg)
 {
-#ifdef __WXMSW__
+#ifdef WIN32
     Sleep(5000);
     ExitProcess(0);
 #endif
@@ -121,10 +121,10 @@ bool AppInit2(int argc, char* argv[])
     // Disable confusing "helpful" text message on abort, ctrl-c
     _set_abort_behavior(0, _WRITE_ABORT_MSG | _CALL_REPORTFAULT);
 #endif
-#ifndef __WXMSW__
+#ifndef WIN32
     umask(077);
 #endif
-#ifndef __WXMSW__
+#ifndef WIN32
     // Clean shutdown on SIGTERM
     struct sigaction sa;
     sa.sa_handler = HandleSIGTERM;
@@ -192,7 +192,7 @@ bool AppInit2(int argc, char* argv[])
 #ifdef GUI
             "  -server          \t\t  " + _("Accept command line and JSON-RPC commands\n") +
 #endif
-#ifndef __WXMSW__
+#ifndef WIN32
             "  -daemon          \t\t  " + _("Run in the background as a daemon and accept commands\n") +
 #endif
             "  -testnet         \t\t  " + _("Use the test network\n") +
@@ -225,7 +225,7 @@ bool AppInit2(int argc, char* argv[])
     fDebug = GetBoolArg("-debug");
     fAllowDNS = GetBoolArg("-dns");
 
-#ifndef __WXMSW__
+#ifndef WIN32
     fDaemon = GetBoolArg("-daemon");
 #else
     fDaemon = false;
@@ -260,7 +260,7 @@ bool AppInit2(int argc, char* argv[])
     }
 #endif
 
-#ifndef __WXMSW__
+#ifndef WIN32
     if (fDaemon)
     {
         // Daemonize
diff --git a/src/main.h b/src/main.h
index 329035dc5a..60ca318381 100644
--- a/src/main.h
+++ b/src/main.h
@@ -927,7 +927,7 @@ public:
         fflush(fileout);
         if (!IsInitialBlockDownload() || (nBestHeight+1) % 500 == 0)
         {
-#ifdef __WXMSW__
+#ifdef WIN32
             _commit(_fileno(fileout));
 #else
             fsync(fileno(fileout));
diff --git a/src/makefile.osx b/src/makefile.osx
index 74af308759..6269d93bda 100644
--- a/src/makefile.osx
+++ b/src/makefile.osx
@@ -28,7 +28,7 @@ LIBS= -dead_strip \
  -lssl \
  -lcrypto
 
-DEFS=-DMSG_NOSIGNAL=0 -DUSE_SSL
+DEFS=-DMAC_OSX -DMSG_NOSIGNAL=0 -DUSE_SSL
 
 DEBUGFLAGS=-g
 # ppc doesn't work because we don't support big-endian
@@ -73,7 +73,7 @@ ifdef USE_UPNP
 	LIBS += -lminiupnpc
 	DEFS += -DUSE_UPNP=$(USE_UPNP)
 endif
-	
+
 
 all: bitcoind
 
diff --git a/src/net.cpp b/src/net.cpp
index 0e861236df..ead7362616 100644
--- a/src/net.cpp
+++ b/src/net.cpp
@@ -10,7 +10,7 @@
 #include "init.h"
 #include "strlcpy.h"
 
-#ifdef __WXMSW__
+#ifdef WIN32
 #include <string.h>
 #endif
 
@@ -102,7 +102,7 @@ bool ConnectSocket(const CAddress& addrConnect, SOCKET& hSocketRet, int nTimeout
     bool fProxy = (fUseProxy && addrConnect.IsRoutable());
     struct sockaddr_in sockaddr = (fProxy ? addrProxy.GetSockAddr() : addrConnect.GetSockAddr());
 
-#ifdef __WXMSW__
+#ifdef WIN32
     u_long fNonblock = 1;
     if (ioctlsocket(hSocket, FIONBIO, &fNonblock) == SOCKET_ERROR)
 #else
@@ -141,7 +141,7 @@ bool ConnectSocket(const CAddress& addrConnect, SOCKET& hSocketRet, int nTimeout
                 return false;
             }
             socklen_t nRetSize = sizeof(nRet);
-#ifdef __WXMSW__
+#ifdef WIN32
             if (getsockopt(hSocket, SOL_SOCKET, SO_ERROR, (char*)(&nRet), &nRetSize) == SOCKET_ERROR)
 #else
             if (getsockopt(hSocket, SOL_SOCKET, SO_ERROR, &nRet, &nRetSize) == SOCKET_ERROR)
@@ -158,7 +158,7 @@ bool ConnectSocket(const CAddress& addrConnect, SOCKET& hSocketRet, int nTimeout
                 return false;
             }
         }
-#ifdef __WXMSW__
+#ifdef WIN32
         else if (WSAGetLastError() != WSAEISCONN)
 #else
         else
@@ -175,7 +175,7 @@ bool ConnectSocket(const CAddress& addrConnect, SOCKET& hSocketRet, int nTimeout
     CNode::ConnectNode immediately turns the socket back to non-blocking
     but we'll turn it back to blocking just in case
     */
-#ifdef __WXMSW__
+#ifdef WIN32
     fNonblock = 0;
     if (ioctlsocket(hSocket, FIONBIO, &fNonblock) == SOCKET_ERROR)
 #else
@@ -674,7 +674,7 @@ CNode* ConnectNode(CAddress addrConnect, int64 nTimeout)
         printf("connected %s\n", addrConnect.ToString().c_str());
 
         // Set to nonblocking
-#ifdef __WXMSW__
+#ifdef WIN32
         u_long nOne = 1;
         if (ioctlsocket(hSocket, FIONBIO, &nOne) == SOCKET_ERROR)
             printf("ConnectSocket() : ioctlsocket nonblocking setting failed, error %d\n", WSAGetLastError());
@@ -1612,7 +1612,7 @@ bool BindListenPort(string& strError)
     int nOne = 1;
     addrLocalHost.port = htons(GetListenPort());
 
-#ifdef __WXMSW__
+#ifdef WIN32
     // Initialize Windows Sockets
     WSADATA wsadata;
     int ret = WSAStartup(MAKEWORD(2,2), &wsadata);
@@ -1638,13 +1638,13 @@ bool BindListenPort(string& strError)
     setsockopt(hListenSocket, SOL_SOCKET, SO_NOSIGPIPE, (void*)&nOne, sizeof(int));
 #endif
 
-#ifndef __WXMSW__
+#ifndef WIN32
     // Allow binding if the port is still in TIME_WAIT state after
     // the program was closed and restarted.  Not an issue on windows.
     setsockopt(hListenSocket, SOL_SOCKET, SO_REUSEADDR, (void*)&nOne, sizeof(int));
 #endif
 
-#ifdef __WXMSW__
+#ifdef WIN32
     // Set to nonblocking, incoming connections will also inherit this
     if (ioctlsocket(hListenSocket, FIONBIO, (u_long*)&nOne) == SOCKET_ERROR)
 #else
@@ -1691,7 +1691,7 @@ void StartNode(void* parg)
     if (pnodeLocalHost == NULL)
         pnodeLocalHost = new CNode(INVALID_SOCKET, CAddress("127.0.0.1", 0, false, nLocalServices));
 
-#ifdef __WXMSW__
+#ifdef WIN32
     // Get local host ip
     char pszHostName[1000] = "";
     if (gethostname(pszHostName, sizeof(pszHostName)) != SOCKET_ERROR)
@@ -1827,7 +1827,7 @@ public:
             if (closesocket(hListenSocket) == SOCKET_ERROR)
                 printf("closesocket(hListenSocket) failed with error %d\n", WSAGetLastError());
 
-#ifdef __WXMSW__
+#ifdef WIN32
         // Shutdown Windows Sockets
         WSACleanup();
 #endif
diff --git a/src/net.h b/src/net.h
index 5b3568fcaf..d847268999 100644
--- a/src/net.h
+++ b/src/net.h
@@ -10,7 +10,7 @@
 #include <boost/foreach.hpp>
 #include <openssl/rand.h>
 
-#ifndef __WXMSW__
+#ifndef WIN32
 #include <arpa/inet.h>
 #endif
 
diff --git a/src/protocol.cpp b/src/protocol.cpp
index 48784b9cfb..f46570e21c 100644
--- a/src/protocol.cpp
+++ b/src/protocol.cpp
@@ -6,7 +6,7 @@
 #include "protocol.h"
 #include "util.h"
 
-#ifndef __WXMSW__
+#ifndef WIN32
 # include <arpa/inet.h>
 #endif
 
diff --git a/src/serialize.h b/src/serialize.h
index 6b35773ac3..396594cf73 100644
--- a/src/serialize.h
+++ b/src/serialize.h
@@ -30,7 +30,7 @@ typedef unsigned long long  uint64;
 #define for  if (false) ; else for
 #endif
 
-#ifdef __WXMSW__
+#ifdef WIN32
 #include <windows.h>
 // This is used to attempt to keep keying material out of swap
 // Note that VirtualLock does not provide this as a guarantee on Windows,
diff --git a/src/util.cpp b/src/util.cpp
index 02e2d21491..236c7f7c44 100644
--- a/src/util.cpp
+++ b/src/util.cpp
@@ -64,7 +64,7 @@ public:
             ppmutexOpenSSL[i] = new boost::interprocess::interprocess_mutex();
         CRYPTO_set_locking_callback(locking_callback);
 
-#ifdef __WXMSW__
+#ifdef WIN32
         // Seed random number generator with screen scrape and other hardware sources
         RAND_screen();
 #endif
@@ -108,7 +108,7 @@ void RandAddSeedPerfmon()
         return;
     nLastPerfmon = GetTime();
 
-#ifdef __WXMSW__
+#ifdef WIN32
     // Don't need this on Linux, OpenSSL automatically uses /dev/urandom
     // Seed with the entire set of perfmon data
     unsigned char pdata[250000];
@@ -198,7 +198,7 @@ inline int OutputDebugStringF(const char* pszFormat, ...)
         }
     }
 
-#ifdef __WXMSW__
+#ifdef WIN32
     if (fPrintToDebugger)
     {
         static CCriticalSection cs_OutputDebugStringF;
@@ -457,7 +457,7 @@ void ParseParameters(int argc, char* argv[])
             pszValue = strchr(psz, '=');
             *pszValue++ = '\0';
         }
-        #ifdef __WXMSW__
+        #ifdef WIN32
         _strlwr(psz);
         if (psz[0] == '/')
             psz[0] = '-';
@@ -648,7 +648,7 @@ bool WildcardMatch(const string& str, const string& mask)
 
 void FormatException(char* pszMessage, std::exception* pex, const char* pszThread)
 {
-#ifdef __WXMSW__
+#ifdef WIN32
     char pszModule[MAX_PATH];
     pszModule[0] = '\0';
     GetModuleFileNameA(NULL, pszModule, sizeof(pszModule));
@@ -707,7 +707,7 @@ void PrintExceptionContinue(std::exception* pex, const char* pszThread)
 
 
 
-#ifdef __WXMSW__
+#ifdef WIN32
 typedef WINSHELLAPI BOOL (WINAPI *PSHGETSPECIALFOLDERPATHA)(HWND hwndOwner, LPSTR lpszPath, int nFolder, BOOL fCreate);
 
 string MyGetSpecialFolderPath(int nFolder, bool fCreate)
@@ -748,7 +748,7 @@ string GetDefaultDataDir()
     // Windows: C:\Documents and Settings\username\Application Data\Bitcoin
     // Mac: ~/Library/Application Support/Bitcoin
     // Unix: ~/.bitcoin
-#ifdef __WXMSW__
+#ifdef WIN32
     // Windows
     return MyGetSpecialFolderPath(CSIDL_APPDATA, true) + "\\Bitcoin";
 #else
@@ -758,7 +758,7 @@ string GetDefaultDataDir()
     string strHome = pszHome;
     if (strHome[strHome.size()-1] != '/')
         strHome += '/';
-#ifdef __WXMAC_OSX__
+#ifdef MAC_OSX
     // Mac
     strHome += "Library/Application Support/";
     filesystem::create_directory(strHome.c_str());
diff --git a/src/util.h b/src/util.h
index 70e1a5599b..178923727a 100644
--- a/src/util.h
+++ b/src/util.h
@@ -7,7 +7,7 @@
 
 #include "uint256.h"
 
-#ifndef __WXMSW__
+#ifndef WIN32
 #include <sys/types.h>
 #include <sys/time.h>
 #include <sys/resource.h>
@@ -81,7 +81,7 @@ T* alignup(T* p)
     return u.ptr;
 }
 
-#ifdef __WXMSW__
+#ifdef WIN32
 #define MSG_NOSIGNAL        0
 #define MSG_DONTWAIT        0
 #ifndef UINT64_MAX
@@ -123,7 +123,7 @@ inline int myclosesocket(SOCKET& hSocket)
 {
     if (hSocket == INVALID_SOCKET)
         return WSAENOTSOCK;
-#ifdef __WXMSW__
+#ifdef WIN32
     int ret = closesocket(hSocket);
 #else
     int ret = close(hSocket);
@@ -192,7 +192,7 @@ std::string GetConfigFile();
 std::string GetPidFile();
 void CreatePidFile(std::string pidFile, pid_t pid);
 void ReadConfigFile(std::map<std::string, std::string>& mapSettingsRet, std::map<std::string, std::vector<std::string> >& mapMultiSettingsRet);
-#ifdef __WXMSW__
+#ifdef WIN32
 std::string MyGetSpecialFolderPath(int nFolder, bool fCreate);
 #endif
 std::string GetDefaultDataDir();
@@ -390,7 +390,7 @@ inline void PrintHex(const std::vector<unsigned char>& vch, const char* pszForma
 inline int64 GetPerformanceCounter()
 {
     int64 nCounter = 0;
-#ifdef __WXMSW__
+#ifdef WIN32
     QueryPerformanceCounter((LARGE_INTEGER*)&nCounter);
 #else
     timeval t;
@@ -424,7 +424,7 @@ void skipspaces(T& it)
 
 inline bool IsSwitchChar(char c)
 {
-#ifdef __WXMSW__
+#ifdef WIN32
     return c == '-' || c == '/';
 #else
     return c == '-';
@@ -467,7 +467,7 @@ inline bool GetBoolArg(const std::string& strArg)
 
 inline void heapchk()
 {
-#ifdef __WXMSW__
+#ifdef WIN32
     /// for debugging
     //if (_heapchk() != _HEAPOK)
     //    DebugBreak();
@@ -626,7 +626,7 @@ public:
 
 // Note: It turns out we might have been able to use boost::thread
 // by using TerminateThread(boost::thread.native_handle(), 0);
-#ifdef __WXMSW__
+#ifdef WIN32
 typedef HANDLE pthread_t;
 
 inline pthread_t CreateThread(void(*pfn)(void*), void* parg, bool fWantHandle=false)
@@ -708,7 +708,7 @@ inline void ExitThread(size_t nExitCode)
 
 inline bool AffinityBugWorkaround(void(*pfn)(void*))
 {
-#ifdef __WXMSW__
+#ifdef WIN32
     // Sometimes after a few hours affinity gets stuck on one processor
     DWORD_PTR dwProcessAffinityMask = -1;
     DWORD_PTR dwSystemAffinityMask = -1;