diff --git a/ci/test/00_setup_env_mac.sh b/ci/test/00_setup_env_mac.sh
index 91652767c4..6270df634a 100755
--- a/ci/test/00_setup_env_mac.sh
+++ b/ci/test/00_setup_env_mac.sh
@@ -14,7 +14,4 @@ export XCODE_BUILD_ID=15A240d
 export RUN_UNIT_TESTS=false
 export RUN_FUNCTIONAL_TESTS=false
 export GOAL="all deploy"
-
-# False-positive warning is fixed with clang 17, remove this when that version
-# can be used.
-export BITCOIN_CONFIG="--with-gui --enable-reduce-exports --disable-miner --with-boost-process LDFLAGS=-Wno-error=unused-command-line-argument"
+export BITCOIN_CONFIG="--with-gui --enable-reduce-exports --disable-miner --with-boost-process"
diff --git a/contrib/guix/manifest.scm b/contrib/guix/manifest.scm
index 51bfad9527..8b632c0b4f 100644
--- a/contrib/guix/manifest.scm
+++ b/contrib/guix/manifest.scm
@@ -609,7 +609,7 @@ inspecting signatures in Mach-O binaries.")
            (list ;; Native GCC 11 toolchain
                  gcc-toolchain-11
                  binutils
-                 clang-toolchain-15
+                 clang-toolchain-17
                  python-signapple
                  xorriso))
           (else '())))))
diff --git a/depends/packages/native_libtapi.mk b/depends/packages/native_libtapi.mk
index a855c393c6..fb5ab0b4dc 100644
--- a/depends/packages/native_libtapi.mk
+++ b/depends/packages/native_libtapi.mk
@@ -6,7 +6,7 @@ $(package)_sha256_hash=d4d46c64622f13d6938cecf989046d9561011bb59e8ee835f8f39825d
 $(package)_patches=disable_zlib.patch
 
 ifeq ($(strip $(FORCE_USE_SYSTEM_CLANG)),)
-$(package)_dependencies=native_clang
+$(package)_dependencies=native_llvm
 endif
 
 define $(package)_preprocess_cmds
diff --git a/depends/packages/native_clang.mk b/depends/packages/native_llvm.mk
similarity index 67%
rename from depends/packages/native_clang.mk
rename to depends/packages/native_llvm.mk
index 661b9c2c1c..09994eb012 100644
--- a/depends/packages/native_clang.mk
+++ b/depends/packages/native_llvm.mk
@@ -1,16 +1,17 @@
-package=native_clang
-$(package)_version=15.0.6
+package=native_llvm
+$(package)_version=17.0.6
+$(package)_major_version=$(firstword $(subst ., ,$($(package)_version)))
 $(package)_download_path=https://github.com/llvm/llvm-project/releases/download/llvmorg-$($(package)_version)
 ifneq (,$(findstring aarch64,$(BUILD)))
 $(package)_file_name=clang+llvm-$($(package)_version)-aarch64-linux-gnu.tar.xz
-$(package)_sha256_hash=8ca4d68cf103da8331ca3f35fe23d940c1b78fb7f0d4763c1c059e352f5d1bec
+$(package)_sha256_hash=6dd62762285326f223f40b8e4f2864b5c372de3f7de0731cb7cd55ca5287b75a
 else
-$(package)_file_name=clang+llvm-$($(package)_version)-x86_64-linux-gnu-ubuntu-18.04.tar.xz
-$(package)_sha256_hash=38bc7f5563642e73e69ac5626724e206d6d539fbef653541b34cae0ba9c3f036
+$(package)_file_name=clang+llvm-$($(package)_version)-x86_64-linux-gnu-ubuntu-22.04.tar.xz
+$(package)_sha256_hash=884ee67d647d77e58740c1e645649e29ae9e8a6fe87c1376be0f3a30f3cc9ab3
 endif
 
 define $(package)_stage_cmds
-  mkdir -p $($(package)_staging_prefix_dir)/lib/clang/$($(package)_version)/include && \
+  mkdir -p $($(package)_staging_prefix_dir)/lib/clang/$($(package)_major_version)/include && \
   mkdir -p $($(package)_staging_prefix_dir)/bin && \
   mkdir -p $($(package)_staging_prefix_dir)/include/llvm-c && \
   cp bin/clang $($(package)_staging_prefix_dir)/bin/ && \
@@ -20,5 +21,5 @@ define $(package)_stage_cmds
   cp include/llvm-c/ExternC.h $($(package)_staging_prefix_dir)/include/llvm-c && \
   cp include/llvm-c/lto.h $($(package)_staging_prefix_dir)/include/llvm-c && \
   cp lib/libLTO.so $($(package)_staging_prefix_dir)/lib/ && \
-  cp -r lib/clang/$($(package)_version)/include/* $($(package)_staging_prefix_dir)/lib/clang/$($(package)_version)/include/
+  cp -r lib/clang/$($(package)_major_version)/include/* $($(package)_staging_prefix_dir)/lib/clang/$($(package)_major_version)/include/
 endef
diff --git a/depends/packages/packages.mk b/depends/packages/packages.mk
index 2e07037ea7..65044553a2 100644
--- a/depends/packages/packages.mk
+++ b/depends/packages/packages.mk
@@ -30,7 +30,7 @@ ifneq ($(build_os),darwin)
 darwin_native_packages += native_cctools native_libtapi
 
 ifeq ($(strip $(FORCE_USE_SYSTEM_CLANG)),)
-darwin_native_packages+= native_clang
+darwin_native_packages+= native_llvm
 endif
 
 endif
diff --git a/depends/packages/qt.mk b/depends/packages/qt.mk
index f8886565d8..6f00cd3559 100644
--- a/depends/packages/qt.mk
+++ b/depends/packages/qt.mk
@@ -23,8 +23,8 @@ $(package)_patches += guix_cross_lib_path.patch
 $(package)_patches += fast_fixed_dtoa_no_optimize.patch
 $(package)_patches += fix-macos-linker.patch
 $(package)_patches += memory_resource.patch
+$(package)_patches += utc_from_string_no_optimize.patch
 $(package)_patches += windows_lto.patch
-$(package)_patches += fix-minimum-macos.patch
 
 $(package)_qttranslations_file_name=qttranslations-$($(package)_suffix)
 $(package)_qttranslations_sha256_hash=a31785948c640b7c66d9fe2db4993728ca07f64e41c560b3625ad191b276ff20
@@ -236,18 +236,18 @@ endef
 define $(package)_preprocess_cmds
   cp $($(package)_patch_dir)/qt.pro qt.pro && \
   cp $($(package)_patch_dir)/qttools_src.pro qttools/src/src.pro && \
-  patch -p1 -i $($(package)_patch_dir)/fix-minimum-macos.patch && \
   patch -p1 -i $($(package)_patch_dir)/fix-macos-linker.patch && \
   patch -p1 -i $($(package)_patch_dir)/dont_hardcode_pwd.patch && \
   patch -p1 -i $($(package)_patch_dir)/fix_qt_pkgconfig.patch && \
   patch -p1 -i $($(package)_patch_dir)/fix_qt_placeholders.patch && \
   patch -p1 -i $($(package)_patch_dir)/fix_android_jni_static.patch && \
   patch -p1 -i $($(package)_patch_dir)/no-xlib.patch && \
+  patch -p1 -i $($(package)_patch_dir)/qtbase-moc-ignore-gcc-macro.patch && \
   patch -p1 -i $($(package)_patch_dir)/use_android_ndk23.patch && \
   patch -p1 -i $($(package)_patch_dir)/memory_resource.patch && \
   patch -p1 -i $($(package)_patch_dir)/rcc_hardcode_timestamp.patch && \
   patch -p1 -i $($(package)_patch_dir)/duplicate_lcqpafonts.patch && \
-  patch -p1 -i $($(package)_patch_dir)/qtbase-moc-ignore-gcc-macro.patch && \
+  patch -p1 -i $($(package)_patch_dir)/utc_from_string_no_optimize.patch && \
   patch -p1 -i $($(package)_patch_dir)/fast_fixed_dtoa_no_optimize.patch && \
   patch -p1 -i $($(package)_patch_dir)/guix_cross_lib_path.patch && \
   patch -p1 -i $($(package)_patch_dir)/windows_lto.patch && \
diff --git a/depends/patches/qt/fix-minimum-macos.patch b/depends/patches/qt/fix-minimum-macos.patch
deleted file mode 100644
index ecaa2ca308..0000000000
--- a/depends/patches/qt/fix-minimum-macos.patch
+++ /dev/null
@@ -1,18 +0,0 @@
-Ensure that Qt handles the minimum macOS version properly
-
-This patch can be dropped for LLVM Clang 17+, after commit
-https://github.com/llvm/llvm-project/commit/c8e2dd8c6f490b68e41fe663b44535a8a21dfeab
-
-
---- a/qtbase/src/corelib/global/qsystemdetection.h
-+++ b/qtbase/src/corelib/global/qsystemdetection.h
-@@ -220,6 +220,9 @@
- #  include <Availability.h>
- #  include <AvailabilityMacros.h>
- #
-+#  undef __MAC_OS_X_VERSION_MIN_REQUIRED
-+#  define __MAC_OS_X_VERSION_MIN_REQUIRED MAC_OS_X_VERSION_MIN_REQUIRED
-+#
- #  ifdef Q_OS_MACOS
- #    if !defined(__MAC_OS_X_VERSION_MIN_REQUIRED) || __MAC_OS_X_VERSION_MIN_REQUIRED < __MAC_10_6
- #       undef __MAC_OS_X_VERSION_MIN_REQUIRED
diff --git a/depends/patches/qt/utc_from_string_no_optimize.patch b/depends/patches/qt/utc_from_string_no_optimize.patch
new file mode 100644
index 0000000000..533ef59b37
--- /dev/null
+++ b/depends/patches/qt/utc_from_string_no_optimize.patch
@@ -0,0 +1,84 @@
+Modify optimisation flags for various functions.
+This fixes non-determinism issues in the asm produced for
+these function when cross-compiling on x86_64 and aarch64 for
+the arm64-apple-darwin HOST.
+
+--- a/qtbase/src/corelib/itemmodels/qitemselectionmodel.cpp
++++ b/qtbase/src/corelib/itemmodels/qitemselectionmodel.cpp
+@@ -1078,9 +1078,9 @@ void QItemSelectionModelPrivate::_q_layoutChanged(const QList<QPersistentModelIn
+ 
+     if (hint != QAbstractItemModel::VerticalSortHint) {
+         // sort the "new" selection, as preparation for merging
+-        std::stable_sort(savedPersistentIndexes.begin(), savedPersistentIndexes.end(),
++        std::sort(savedPersistentIndexes.begin(), savedPersistentIndexes.end(),
+                          qt_PersistentModelIndexLessThan);
+-        std::stable_sort(savedPersistentCurrentIndexes.begin(), savedPersistentCurrentIndexes.end(),
++        std::sort(savedPersistentCurrentIndexes.begin(), savedPersistentCurrentIndexes.end(),
+                          qt_PersistentModelIndexLessThan);
+ 
+         // update the selection by merging the individual indexes
+@@ -1092,8 +1092,8 @@ void QItemSelectionModelPrivate::_q_layoutChanged(const QList<QPersistentModelIn
+         savedPersistentCurrentIndexes.clear();
+     } else {
+         // sort the "new" selection, as preparation for merging
+-        std::stable_sort(savedPersistentRowLengths.begin(), savedPersistentRowLengths.end());
+-        std::stable_sort(savedPersistentCurrentRowLengths.begin(), savedPersistentCurrentRowLengths.end());
++        std::sort(savedPersistentRowLengths.begin(), savedPersistentRowLengths.end());
++        std::sort(savedPersistentCurrentRowLengths.begin(), savedPersistentCurrentRowLengths.end());
+ 
+         // update the selection by merging the individual indexes
+         ranges = mergeRowLengths(savedPersistentRowLengths);
+
+--- a/qtbase/src/corelib/itemmodels/qitemselectionmodel_p.h
++++ b/qtbase/src/corelib/itemmodels/qitemselectionmodel_p.h
+@@ -76,7 +76,7 @@ public:
+     void _q_rowsAboutToBeInserted(const QModelIndex &parent, int start, int end);
+     void _q_columnsAboutToBeInserted(const QModelIndex &parent, int start, int end);
+     void _q_layoutAboutToBeChanged(const QList<QPersistentModelIndex> &parents = QList<QPersistentModelIndex>(), QAbstractItemModel::LayoutChangeHint hint = QAbstractItemModel::NoLayoutChangeHint);
+-    void _q_layoutChanged(const QList<QPersistentModelIndex> &parents = QList<QPersistentModelIndex>(), QAbstractItemModel::LayoutChangeHint hint = QAbstractItemModel::NoLayoutChangeHint);
++    __attribute__ ((optnone)) void _q_layoutChanged(const QList<QPersistentModelIndex> &parents = QList<QPersistentModelIndex>(), QAbstractItemModel::LayoutChangeHint hint = QAbstractItemModel::NoLayoutChangeHint);
+ 
+     inline void remove(QList<QItemSelectionRange> &r)
+     {
+
+--- a/qtbase/src/corelib/time/qdatetimeparser_p.h
++++ b/qtbase/src/corelib/time/qdatetimeparser_p.h
+@@ -215,7 +215,7 @@ private:
+             : value(ok == Invalid ? -1 : val), used(read), zeroes(zs), state(ok)
+             {}
+     };
+-    ParsedSection parseSection(const QDateTime &currentValue, int sectionIndex,
++    __attribute__ ((optnone)) ParsedSection parseSection(const QDateTime &currentValue, int sectionIndex,
+                                int offset, QString *text) const;
+     int findMonth(const QString &str1, int monthstart, int sectionIndex,
+                   int year, QString *monthName = nullptr, int *used = nullptr) const;
+
+--- a/qtbase/src/corelib/time/qtimezoneprivate_p.h
++++ b/qtbase/src/corelib/time/qtimezoneprivate_p.h
+@@ -191,7 +191,7 @@ public:
+     virtual ~QUtcTimeZonePrivate();
+ 
+     // Fall-back for UTC[+-]\d+(:\d+){,2} IDs.
+-    static qint64 offsetFromUtcString(const QByteArray &id);
++    static __attribute__ ((optnone)) qint64 offsetFromUtcString(const QByteArray &id);
+ 
+     QUtcTimeZonePrivate *clone() const override;
+ 
+--- a/qtbase/src/widgets/widgets/qcalendarwidget.cpp
++++ b/qtbase/src/widgets/widgets/qcalendarwidget.cpp
+@@ -329,13 +329,13 @@ class QCalendarYearValidator : public QCalendarDateSectionValidator
+ 
+ public:
+     QCalendarYearValidator();
+-    virtual Section handleKey(int key) override;
++    __attribute__ ((optnone)) virtual Section handleKey(int key) override;
+     virtual QDate applyToDate(QDate date, QCalendar cal) const override;
+     virtual void setDate(QDate date, QCalendar cal) override;
+     virtual QString text() const override;
+     virtual QString text(QDate date, QCalendar cal, int repeat) const override;
+ private:
+-    int pow10(int n);
++    __attribute__ ((optnone)) int pow10(int n);
+     int m_pos;
+     int m_year;
+     int m_oldYear;