diff --git a/.gitlab-ci.yml b/.gitlab-ci.yml
index 25ac730fbc..9a60351fcc 100644
--- a/.gitlab-ci.yml
+++ b/.gitlab-ci.yml
@@ -252,6 +252,15 @@ linux64_fuzz-build:
   variables:
     BUILD_TARGET: linux64_fuzz
 
+linux64_asan-build:
+  extends:
+    - .build-template
+    - .skip-in-fast-mode-template
+  needs:
+    - x86_64-pc-linux-gnu-debug
+  variables:
+    BUILD_TARGET: linux64_asan
+
 linux64_tsan-build:
   extends:
     - .build-template
@@ -315,6 +324,15 @@ linux64_sqlite-test:
   variables:
     BUILD_TARGET: linux64_sqlite
 
+linux64_asan-test:
+  extends:
+    - .test-template
+    - .skip-in-fast-mode-template
+  needs:
+    - linux64_asan-build
+  variables:
+    BUILD_TARGET: linux64_asan
+
 linux64_tsan-test:
   extends:
     - .test-template
diff --git a/ci/dash/matrix.sh b/ci/dash/matrix.sh
index b9ba18b3b9..26dcba42ef 100755
--- a/ci/dash/matrix.sh
+++ b/ci/dash/matrix.sh
@@ -11,6 +11,8 @@ export LC_ALL=C.UTF-8
 source ./ci/test/00_setup_env.sh
 
 # Configure sanitizers options
+export ASAN_OPTIONS=""
+export LSAN_OPTIONS="suppressions=${BASE_ROOT_DIR}/test/sanitizer_suppressions/lsan"
 export TSAN_OPTIONS="suppressions=${BASE_ROOT_DIR}/test/sanitizer_suppressions/tsan"
 export UBSAN_OPTIONS="suppressions=${BASE_ROOT_DIR}/test/sanitizer_suppressions/ubsan"
 
@@ -20,6 +22,8 @@ elif [ "$BUILD_TARGET" = "win64" ]; then
   source ./ci/test/00_setup_env_win64.sh
 elif [ "$BUILD_TARGET" = "linux64" ]; then
   source ./ci/test/00_setup_env_native_qt5.sh
+elif [ "$BUILD_TARGET" = "linux64_asan" ]; then
+  source ./ci/test/00_setup_env_native_asan.sh
 elif [ "$BUILD_TARGET" = "linux64_tsan" ]; then
   source ./ci/test/00_setup_env_native_tsan.sh
 elif [ "$BUILD_TARGET" = "linux64_ubsan" ]; then
diff --git a/ci/test/00_setup_env_native_asan.sh b/ci/test/00_setup_env_native_asan.sh
new file mode 100644
index 0000000000..0e15669347
--- /dev/null
+++ b/ci/test/00_setup_env_native_asan.sh
@@ -0,0 +1,14 @@
+#!/usr/bin/env bash
+#
+# Copyright (c) 2019 The Bitcoin Core developers
+# Distributed under the MIT software license, see the accompanying
+# file COPYING or http://www.opensource.org/licenses/mit-license.php.
+
+export LC_ALL=C.UTF-8
+
+export PACKAGES="clang llvm python3-zmq qtbase5-dev qttools5-dev-tools libevent-dev bsdmainutils libboost-filesystem-dev libboost-test-dev libboost-thread-dev libdb5.3++-dev libminiupnpc-dev libzmq3-dev libqrencode-dev"
+export NO_DEPENDS=1
+export FUNCTIONAL_TESTS_CONFIG="--exclude wallet_multiwallet.py" # Temporarily suppress ASan heap-use-after-free (see issue #14163)
+export RUN_BENCH=true
+export GOAL="install"
+export BITCOIN_CONFIG="--enable-zmq --with-incompatible-bdb --with-gui=qt5 CPPFLAGS=-DDEBUG_LOCKORDER --with-sanitizers=address,integer,undefined CC=clang CXX=clang++"