diff --git a/ci/test/00_setup_env_mac.sh b/ci/test/00_setup_env_mac.sh
index befdb2dbab..774539e524 100755
--- a/ci/test/00_setup_env_mac.sh
+++ b/ci/test/00_setup_env_mac.sh
@@ -8,7 +8,7 @@ export LC_ALL=C.UTF-8
 
 export CONTAINER_NAME=ci_macos_cross
 export HOST=x86_64-apple-darwin
-export PACKAGES="cmake libcap-dev libz-dev libbz2-dev python3-dev python3-setuptools"
+export PACKAGES="cmake libcap-dev libz-dev libbz2-dev python3-setuptools"
 export XCODE_VERSION=12.2
 export XCODE_BUILD_ID=12B45b
 export RUN_UNIT_TESTS=false
diff --git a/contrib/gitian-descriptors/gitian-osx.yml b/contrib/gitian-descriptors/gitian-osx.yml
index 635e8a1f7a..4a05cf3e12 100644
--- a/contrib/gitian-descriptors/gitian-osx.yml
+++ b/contrib/gitian-descriptors/gitian-osx.yml
@@ -21,7 +21,6 @@ packages:
 - "libz-dev"
 - "libbz2-dev"
 - "python3"
-- "python3-dev"
 - "python3-setuptools"
 - "python3-pip"
 - "fonts-tuffy"