diff --git a/.gitlab-ci.yml b/.gitlab-ci.yml
index 95458e4ce6..9b6457c9e3 100644
--- a/.gitlab-ci.yml
+++ b/.gitlab-ci.yml
@@ -42,7 +42,7 @@ builder-image:
   before_script:
     - echo HOST=$HOST
     - |
-      if [ "$HOST" = "x86_64-apple-darwin14" ]; then
+      if [ "$HOST" = "x86_64-apple-darwin16" ]; then
         echo "Downloading MacOS SDK"
         mkdir -p depends/SDKs
         mkdir -p depends/sdk-sources
@@ -187,12 +187,12 @@ x86_64-unknown-linux-gnu-release:
     HOST: x86_64-unknown-linux-gnu
     DEP_OPTS: "NO_UPNP=1"
 
-x86_64-apple-darwin14:
+x86_64-apple-darwin16:
   extends:
     - .build-depends-template
     - .skip-in-fast-mode-template
   variables:
-    HOST: x86_64-apple-darwin14
+    HOST: x86_64-apple-darwin16
 
 ###
 
@@ -267,7 +267,7 @@ mac-build:
     - .build-template
     - .skip-in-fast-mode-template
   needs:
-    - x86_64-apple-darwin14
+    - x86_64-apple-darwin16
   variables:
     BUILD_TARGET: mac
 
diff --git a/.travis.yml b/.travis.yml
index 86d7e695c2..b1ae558a90 100644
--- a/.travis.yml
+++ b/.travis.yml
@@ -310,9 +310,9 @@ after_success:
         BITCOIN_CONFIG="--enable-glibc-back-compat --enable-reduce-exports"
 
     - stage: test
-      name: 'macOS 10.10  [GOAL: deploy]'
+      name: 'macOS 10.12  [GOAL: deploy]'
       env: >-
-        HOST=x86_64-apple-darwin14
+        HOST=x86_64-apple-darwin16
         PACKAGES="cmake imagemagick libcap-dev librsvg2-bin libz-dev libbz2-dev libtiff-tools python-dev python3-setuptools-git"
         OSX_SDK=10.11
         RUN_UNIT_TESTS=false
diff --git a/CMakeLists.txt b/CMakeLists.txt
index 8de9b0a2b2..fb78ca81fa 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -20,7 +20,7 @@ include_directories(
 if(UNIX AND NOT APPLE)
     set(DEPENDS_PREFIX depends/x86_64-pc-linux-gnu)
 elseif(APPLE)
-    set(DEPENDS_PREFIX depends/x86_64-apple-darwin14)
+    set(DEPENDS_PREFIX depends/x86_64-apple-darwin16)
 elseif(WIN32)
     set(DEPENDS_PREFIX depends/x86_64-w64-mingw32)
 endif()
diff --git a/ci/matrix.sh b/ci/matrix.sh
index 6f306c1d4e..bf139f96bc 100755
--- a/ci/matrix.sh
+++ b/ci/matrix.sh
@@ -81,7 +81,7 @@ elif [ "$BUILD_TARGET" = "linux64_release" ]; then
   export BITCOIN_CONFIG="--enable-zmq --enable-glibc-back-compat --enable-reduce-exports"
   export PYZMQ=true
 elif [ "$BUILD_TARGET" = "mac" ]; then
-  export HOST=x86_64-apple-darwin14
+  export HOST=x86_64-apple-darwin16
   export BITCOIN_CONFIG="--enable-gui --enable-reduce-exports --disable-miner"
   export OSX_SDK=10.11
   export GOAL="all deploy"
diff --git a/contrib/gitian-descriptors/gitian-osx.yml b/contrib/gitian-descriptors/gitian-osx.yml
index c02c25e35d..ced7e75349 100644
--- a/contrib/gitian-descriptors/gitian-osx.yml
+++ b/contrib/gitian-descriptors/gitian-osx.yml
@@ -38,7 +38,7 @@ script: |
   set -e -o pipefail
 
   WRAP_DIR=$HOME/wrapped
-  HOSTS="x86_64-apple-darwin14"
+  HOSTS="x86_64-apple-darwin16"
   CONFIGFLAGS="--enable-reduce-exports --disable-miner --disable-bench --disable-gui-tests GENISOIMAGE=$WRAP_DIR/genisoimage --enable-crash-hooks"
   FAKETIME_HOST_PROGS=""
   FAKETIME_PROGS="ar ranlib date dmg genisoimage"
@@ -188,8 +188,8 @@ script: |
   done
   mkdir -p $OUTDIR/src
   mv $SOURCEDIST $OUTDIR/src
-  mv ${OUTDIR}/${DISTNAME}-x86_64-apple-darwin14.tar.gz ${OUTDIR}/${DISTNAME}-osx64.tar.gz
-  mv ${OUTDIR}/${DISTNAME}-x86_64-apple-darwin14-debug.tar.gz ${OUTDIR}/${DISTNAME}-osx64-debug.tar.gz
+  mv ${OUTDIR}/${DISTNAME}-x86_64-apple-darwin16.tar.gz ${OUTDIR}/${DISTNAME}-osx64.tar.gz
+  mv ${OUTDIR}/${DISTNAME}-x86_64-apple-darwin16-debug.tar.gz ${OUTDIR}/${DISTNAME}-osx64-debug.tar.gz
 
   # Compress ccache (otherwise the assert file will get too huge)
   if [ "$CCACHE_DIR" != "" ]; then
diff --git a/depends/README.md b/depends/README.md
index 6a9a87be16..3378a0e934 100644
--- a/depends/README.md
+++ b/depends/README.md
@@ -22,7 +22,7 @@ Common `host-platform-triplets` for cross compilation are:
 
 - `i686-w64-mingw32` for Win32
 - `x86_64-w64-mingw32` for Win64
-- `x86_64-apple-darwin14` for macOS
+- `x86_64-apple-darwin16` for macOS
 - `arm-linux-gnueabihf` for Linux ARM 32 bit
 - `aarch64-linux-gnu` for Linux ARM 64 bit
 - `riscv32-linux-gnu` for Linux RISC-V 32 bit
diff --git a/depends/hosts/darwin.mk b/depends/hosts/darwin.mk
index a1c943d60b..1f88c209cf 100644
--- a/depends/hosts/darwin.mk
+++ b/depends/hosts/darwin.mk
@@ -1,4 +1,4 @@
-OSX_MIN_VERSION=10.10
+OSX_MIN_VERSION=10.12
 OSX_SDK_VERSION=10.11
 OSX_SDK=$(SDK_PATH)/MacOSX$(OSX_SDK_VERSION).sdk
 LD64_VERSION=253.9
diff --git a/doc/build-cross.md b/doc/build-cross.md
index 119a1208cb..b568bfe0c9 100644
--- a/doc/build-cross.md
+++ b/doc/build-cross.md
@@ -26,13 +26,13 @@ $ tar -C depends/SDKs -xf depends/sdk-sources/MacOSX10.11.sdk.tar.gz
 When building the dependencies, as described in [build-generic](build-generic.md), use
 
 ```bash
-$ make HOST=x86_64-apple-darwin14 -j4
+$ make HOST=x86_64-apple-darwin16 -j4
 ```
 
 When building Dash Core, use
 
 ```bash
-$ ./configure --prefix=`pwd`/depends/x86_64-apple-darwin14
+$ ./configure --prefix=`pwd`/depends/x86_64-apple-darwin16
 ```
 
 Windows 64bit Cross-compilation
diff --git a/doc/build-generic.md b/doc/build-generic.md
index b4845dbcd3..deb83ebd1a 100644
--- a/doc/build-generic.md
+++ b/doc/build-generic.md
@@ -49,7 +49,7 @@ Please replace `<host>` with your local system's `host-platform-triplet`. The fo
 - `x86_64-pc-linux-gnu` for Linux64
 - `i686-w64-mingw32` for Win32
 - `x86_64-w64-mingw32` for Win64
-- `x86_64-apple-darwin14` for MacOSX
+- `x86_64-apple-darwin16` for MacOSX
 - `arm-linux-gnueabihf` for Linux ARM 32 bit
 - `aarch64-linux-gnu` for Linux ARM 64 bit
 
diff --git a/share/qt/Info.plist.in b/share/qt/Info.plist.in
index 6e6d759c48..12c661d016 100644
--- a/share/qt/Info.plist.in
+++ b/share/qt/Info.plist.in
@@ -3,7 +3,7 @@
 <plist version="0.9">
 <dict>
   <key>LSMinimumSystemVersion</key>
-  <string>10.10.0</string>
+  <string>10.12.0</string>
 
   <key>LSArchitecturePriority</key>
   <array>