diff --git a/contrib/guix/libexec/build.sh b/contrib/guix/libexec/build.sh
index c357a9da49..d07bde6730 100755
--- a/contrib/guix/libexec/build.sh
+++ b/contrib/guix/libexec/build.sh
@@ -63,7 +63,6 @@ store_path() {
 # Set environment variables to point the NATIVE toolchain to the right
 # includes/libs
 NATIVE_GCC="$(store_path gcc-toolchain)"
-NATIVE_GCC_STATIC="$(store_path gcc-toolchain static)"
 
 unset LIBRARY_PATH
 unset CPATH
@@ -72,12 +71,21 @@ unset CPLUS_INCLUDE_PATH
 unset OBJC_INCLUDE_PATH
 unset OBJCPLUS_INCLUDE_PATH
 
-export LIBRARY_PATH="${NATIVE_GCC}/lib:${NATIVE_GCC_STATIC}/lib"
 export C_INCLUDE_PATH="${NATIVE_GCC}/include"
 export CPLUS_INCLUDE_PATH="${NATIVE_GCC}/include/c++:${NATIVE_GCC}/include"
 export OBJC_INCLUDE_PATH="${NATIVE_GCC}/include"
 export OBJCPLUS_INCLUDE_PATH="${NATIVE_GCC}/include/c++:${NATIVE_GCC}/include"
 
+case "$HOST" in
+    *darwin*)
+        export LIBRARY_PATH="${NATIVE_GCC}/lib"
+        ;;
+    *)
+        NATIVE_GCC_STATIC="$(store_path gcc-toolchain static)"
+        export LIBRARY_PATH="${NATIVE_GCC}/lib:${NATIVE_GCC_STATIC}/lib"
+        ;;
+esac
+
 # Set environment variables to point the CROSS toolchain to the right
 # includes/libs for $HOST
 case "$HOST" in
diff --git a/contrib/guix/manifest.scm b/contrib/guix/manifest.scm
index 604e27ea6f..81f186b1d2 100644
--- a/contrib/guix/manifest.scm
+++ b/contrib/guix/manifest.scm
@@ -588,9 +588,8 @@ inspecting signatures in Mach-O binaries.")
                  (list gcc-toolchain-12 "static")
                  (make-bitcoin-cross-toolchain target)))
           ((string-contains target "darwin")
-           (list ;; Native GCC 10 toolchain
-                 gcc-toolchain-10
-                 (list gcc-toolchain-10 "static")
+           (list ;; Native GCC 11 toolchain
+                 gcc-toolchain-11
                  binutils
                  clang-toolchain-10
                  python-signapple